Devon Lawson

Devon A Lawson, Ph.D.

Associate Professor, Physiology & Biophysics
Office 112 Sprague Hall
Phone: (949) 824-4113

Dr. Lawson is also a member of the Chao Family Comprehensive Cancer Center. Dr. Lawson’s work focuses on the molecular mechanisms that drive breast cancer metastasis using single-cell genomics. She reported that metastatic cells express a distinct gene expression profile akin to normal breast epithelial stem cells (Nature, 2015). Using single-cell transcriptomic analysis, she recently identify a metabolic shift from glycolysis to mitochondrial oxidative phosphorylation that is important for cancer cell metastasis (Nat. Cell Biol., 2020), and is currently using single-cell technologies to investigate the role of microglia in controlling the immune response to breast cancer brain metastasis. Dr. Lawson has trained 3 postdoctoral fellows, 6 pre-doctoral students, and 11 undergraduates. One of her graduate students, Ryan Davis, graduated in August 2020. Katrina Evans, who was a T32 trainee on this grant and graduated in July, 2021, has a first-author paper describing CNS immunity in brain metastasis under review in Nature Cell Biology. Dr. Lawson’s new students, Aaron Longworth and Paige Halas, are training grant eligible.

IFI Research Focus Area(s): Cancer Immunology and Immunotherapy
immune responses in breast cancer metastases to the brain

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