Dr. Lawson is also a member of the Chao Family Comprehensive Cancer Center. Dr. Lawson’s work focuses on the molecular mechanisms that drive breast cancer metastasis using single-cell genomics. She reported that metastatic cells express a distinct gene expression profile akin to normal breast epithelial stem cells (Nature, 2015). Using single-cell transcriptomic analysis, she recently identify a metabolic shift from glycolysis to mitochondrial oxidative phosphorylation that is important for cancer cell metastasis (Nat. Cell Biol., 2020), and is currently using single-cell technologies to investigate the role of microglia in controlling the immune response to breast cancer brain metastasis. Dr. Lawson has trained 3 postdoctoral fellows, 6 pre-doctoral students, and 11 undergraduates. One of her graduate students, Ryan Davis, graduated in August 2020. Katrina Evans, who was a T32 trainee on this grant and graduated in July, 2021, has a first-author paper describing CNS immunity in brain metastasis under review in Nature Cell Biology. Dr. Lawson’s new students, Aaron Longworth and Paige Halas, are training grant eligible.