Tom Lane

Thomas E. Lane, Ph.D.

Chancellor's Professor in Neurobiology & Behavior and Director of the Center for Virus Research
Office 2213 McGaugh Hall
Phone: (949) 824-1360

Dr. Lane’s research uses a murine coronavirus to examine molecular and cellular mechanisms governing neuroinflammation, demyelination, and remyelination in pre-clinical models of the human demyelinating disease multiple sclerosis (MS). Specifically, he uses an animal model of neuroinflammatory-mediated demyelination induced by infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV, a member of the Coronaviridae family of viruses) to identify roles for chemokines and chemokine receptors. Dr. Lane was at UCI from 1998-2013 (and was Associate Director of the IFI), when he moved to the University of Utah; however, he returned to UCI in 2020 and, as noted above, is using a murine model to examine neurological outcomes of COVID-19.

IFI Research Focus Area(s): Host Defense and Vaccine Development
coronaviruses, multiple sclerosis

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