Dr. Blurton-Jones’ s research utilizes human induced pluripotent stem cells (iPSC) and chimeric mouse models to examine the underlying molecular mechanisms that drive the development and progression of Alzheimer’s disease (AD). In recent studies, he developed novel chimeric mouse models that demonstrated cross-talk between adaptive and innate immunity, which likely plays an integral role in AD. Dr. Matt Blurton-Jones was listed as a junior preceptor in the 2015 submission of this grant proposal, and has graduated 4 students, all of whom earned PhDs within 5 years and are pursuing postdoctoral training or employment within biomedical-related fields. Currently he has 6 graduate students who are Training Grant Eligible.