Aileen Anderson

Aileen Anderson, Ph.D.

Professor of Physical Medicine & Rehabilitation and Director of the Sue and Bill Gross Stem Cell Research Center
Phone: (949) 824-6750

Dr. Anderson’s research program examines central nervous system (CNS) degeneration and regeneration, especially the role of human neural stem cells in thoracic spinal cord injury (SCI). The Anderson lab examines non-traditional roles for the innate inflammatory system in both the pathophysiology of spinal cord injury, and identified a role for complement C1q and C3a/C3b as single molecules in the CNS, controlling mouse and human neutral stem cell behavior, and thereby identifying a key role for innate immune cells and autocrine / paracrine complement signaling in survival, self-renewal, and differentiation in the adult brain, as well as a role for these proteins in age-related neurogenesis declines. Dr. Anderson has mentored eight Ph.D. students and co-mentored three Ph.D. students who have completed their dissertations. She currently has three Ph.D. students in her lab.

IFI Research Focus Area(s): Neurodegenerative Disease and Microglia Biology
stem cells, innate immunity in spinal cord injury

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