Integrative Immunology

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Integrative Immunology

215A
2034 Gross Hall (Stem Cell Research Center)
Tuesday/Thursday, 2:30 - 3:50PM
Classes will be held live and in person and attendance is mandatory.

Course Coordinators

Eric Pearlman
Matt Inlay
Francesco Marangoni

Description

This is the first part of a two-quarters course covering basic and advanced concepts in immunology. The course will also cover in-depth analyses of selected topics within the broader field of immunology, including relevant research techniques, while improving critical thinking skills. There will be a combination of didactic lectures with discussions of primary literature.

Course title note: Please note that this class is entitled Integrative Immunology I, and is organized by faculty in two departments: Molecular Biology & Biochemistry, and Physiology and Biophysics. The class is cross listed as MOL BIO 215A (MB215A) and PHYSIO 215A (PB215A). It is the same class.

Time and Place:

Tuesday/Thursday, 2:30-3:50 pm in 2034 Gross Hall (Stem Cell Research Center). Classes will be held live and in person and attendance is mandatory.

Text (Recommended)

Janeway’s Immunobiology, Garland Science, 9th Edition. Copies are available at the UCI bookstore. This book is also available as an e-book through Vital Source, including the option of renting the book or purchasing individual chapters:

Please note that while we will only cover selected chapters of the textbook, the text would be a good resource during graduate school. If you want to borrow a copy, talk to the course organizers, as some copies may be available. Additional reading material will be posted on the course website, in PDF format.

Attendance

Attendance is mandatory for all classes and journal clubs, one excused absence allowed.

Grading

Grading in the class will be based on 2 measures: 1) participation in the class and the paper discussions, and 2) weekly take-home challenge questions and final exam.

100 points total:
33% participation in class and paper discussions
67% worksheets and final exam

Paper discussions

After a lecture covering a topic is given, a journal article on that topic will be discussed the following class. All students are expected to read the paper and participate in the discussion via the following format:

Each week, a group of 4-6 students will be assigned the paper, and will organize amongst themselves how to present it to the class. The presenters have flexibility to organize themselves for how they present it, but we suggest that 1-2 students present a background on the subject of the paper, and then 1-2 students present each figure. 1 student should also present the main conclusions and future directions. Non-presenting students in class are expected to ask questions and provide critical evaluation of the paper of what they liked and didn't like. Instructors may call upon individual students to ask for their opinions or input. Special attention should be paid to: whether the authors' conclusions are supported by data, whether appropriate statistical tests were used, how robust the phenotypes are, whether the experimental flow is logical, and what impact the paper has on the field.

The remaining students are expected to ask questions and provide critical evaluation of the paper.

Participation:  Participation in class is mandatory.  This includes attendance, the quality of your presentations in the journal discussions, and asking questions and/or providing insight/analysis in the lectures and journal discussions.  Each instructor will assign a participation grade based on these items.

Weekly worksheets: After each journal discussion (Thursdays), the students will receive 3-4 questions as a take-home assignment, and will have until the next lecture (the following Tuesday) to upload their answers in CANVAS. Students may discuss the problems and their answers in groups, but must submit their own answers in their own writing.  It is encouraged to work on these in small groups and discuss answers with your peers, but you must understand the answers and write them yourself.  You are also accountable for the answers you provide, including if a peer gave you an answer that was generated through prohibited use of AI (see next section).

Admissible use of AI: Students are permitted to utilize AI as a study aid. Specifically, AI usage is allowed to i) perform searches for sources of information; ii) confirm the students’ understanding of complex concepts, iii) check grammar (but NOT to generate answers – see next paragraph). If any student uses AI for these allowed purposes, a sentence declaring the specific purpose of AI usage and how it was used (including which software) must be included in their answers.

Prohibited use of AI: The use of AI to generate the answers to the worksheets’ questions, including copying and pasting from an AI agent, is strictly forbidden. Rather, the students will use their own ability to analyze and synthesize the concepts learned in the lessons and write the answers on their own. Blatant use of AI to produce answers to the assignments will be sanctioned by a grade of 0 on the specific assignment (first offense). In cases of multiple offenses, the course directors will determine the appropriate course of action.

Final Exam

The final will be in person and hand written, with no notes or computers allowed.  The format will be similar to the weekly worksheets but will include questions spanning the entire class.  The test is designed to be easy for those who completed the worksheet questions and understood the answers.

Evaluation of instructors:

The students’ feedback on the quality of lessons and teachers is a key tool for the continuous improvement of the course.  Extra credit will be given for evaluation submission.

 

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