Marian Waterman, Ph.D.
Wnt signaling, cancer, gene expression, development; intestine; stem cells; LEF and TCF transcription factors
The goal of research in the Waterman laboratory is to understand how the Wnt signaling pathway regulates target genes through the actions of LEF/TCF transcription factors. Dysfunctional Wnt signals misregulate gene expression and cause cancer and most of our work on LEF/TCFs is within the context of the final step of this dysregulated pathway. LEF/TCF proteins bind to Wnt Response Elements in target genes and recruit ß-catenin for gene activation or repressors for gene silencing. There are two main areas of research: 1) Regulation of LEF/TCF expression, and 2) Structure and activities of LEF/TCFs. Our work in these two areas has led to new insights on LEF/TCF structure, Wnt response element recognition, signals from the tumor microenvironment and chromatin regulators that modify the types and amounts of LEF/TCFs. In almost every aspect LEF/TCF expression and/or function has been distorted in cancer.
224 Sprague Hall
240 Sprague Hall