Manuela Raffatellu, M.D.
Manuela Raffatellu has worked as a researcher in Italy, Denmark, Texas, and Northern California before establishing her own laboratory at the University of California, Irvine in 2008. She has been interested in infectious diseases and bacterial pathogenesis since medical school. She also likes going to the beach (which is 10 minutes away from Campus!) eating authentic Italian food, and going back to her hometown in the island of Sardinia.
The goal of our research is to understand how mucosal responses are orchestrated in response to mucosal pathogens like Salmonella typhimurium. The mucosal immune response has the important function of containing an infection and preventing dissemination of pathogens to systemic sites. However, there is increasing evidence that mucosal pathogens achieve greater colonization during inflammation. Thus, mucosal responses constitute a double-edge sword: on one end, these responses are necessary to contain an infection to the mucosa, and on the other end they favor pathogens colonization. We are interested in investigating this dichotomy of the host response, and understanding which responses constitute the mucosal barrier during S. typhimurium infection and which ones favor S. typhimurium colonization of the inflamed gut.
B251 Med Sci I
B260 Med Sci I