N-glycosylation is a critical regulator of T cell function. The branching and number of N-glycans on cell surface glycoproteins drive binding to galectins, forming a galectin-glycoprotein lattice that controls T cell growth, differentiation and development by regulating receptor clustering, distribution and endocytosis. N-glycan branching is ~1.5-2 fold higher in B cells compared to T cells, yet effects on B cell function are unknown.
My research focuses on investigating the role of N-glycan branching on B cell development and function. My findings suggest N-glycan branching is essential in regulating B cell selection during development, as well as maintaining normal peripheral B cell effector functions by limiting pro-inflammatory responses.
250 Sprague Hall
250 Sprague Hall Room