Marley Hilleger

Overview

Marley is a graduate student in the Wunderlich lab.

Research Interests

During infection, many genes are rapidly up-regulated as part of the innate immune response to fight off invading pathogens. The instructions for which genes should be up-regulated and the timing and severity of the response are encoded in the genome. Enhancers make up a significant portion of these instructions as they play a critical role in specifying when, where, and to what extent a gene is transcribed. Extensive work in the common fly model, Drosophila, has identified two major signaling pathways (Toll and IMD) and characterized four transcription factors (TFs) (three REL/NF-kB-family factors and one GATA factor) that largely drive the immune response. But, despite the fact that there are hundreds of immune responsive genes, there is only qualitative data for ~10 enhancers. My goal is to identify immune-responsive enhancers genome-wide and characterize what properties of enhancers allow genes to be reliably induced upon infection.


Website(s)

Office

4432 Natural Sciences II
(949) 824-5498

Lab

4432 Natural Sciences II
(949) 824-5498