Kim Green, Ph.D.
Dr. Green is Associate Professor of Neurobiology and Behavior.
My research interests are focused on microglia, the immune cell of the brain. We discovered that microglia in the adult brain are dependent upon signaling through the colony-stimulating factor 1 receptor (CSF1R) for their survival, and that we could take advantage of this dependency through the administration of specific CSF1R inhibitors leading to the rapid and sustained elimination of >95% of all microglia from the CNS. Through this method we are studying the roles that microglia play in normal brain function, as well as their effects on the brain during disease and injury. In particular, we are interested in elucidating the roles that microglia play in the initiation and pathogenesis of Alzheimer's disease, as well as during and after neuronal injury.
We also uncovered that once the brain has been depleted of microglia withdrawal of CSF1R inhibitors leads to the rapid repopulation of the entire CNS by progenitor cells that then differentiate into new microglia, all within a few days. This is the first description of a microglial progenitor and we are now exploring these cells to determine their properties and if they have any therapeutic potential.
3208 Biological Sciences III
3422 Biological Sciences III