David Fruman, Ph.D.


Major interests include Signaling, Lymphocyte Activation, Leukemogenesis, Gene Expression

Research Interests

The focus of research in my laboratory is signal transduction in lymphocytes and leukemia cells. Our long-term goal is to define signaling components whose function is specific to particular immune cell types or responses. Our rationale is that such components could prove useful as therapeutic targets for immunological diseases and cancer. Phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) are two signaling enzymes that have well-established roles in control of growth and survival of both normal and cancer cells. The PI3K/mTOR pathway is complex, with many inputs, outputs and feedback loops. Work in my laboratory is divided into two general areas: (1) Specificity of PI3K signaling in immune cells; (2) Targeting the PI3K/mTOR pathway in leukemia and autoimmune diseases.



3242 McGaugh Hall
(949) 824-1947


3407 McGaugh Hall
(949) 824-2274