Honyin Chiu

Overview

Honyin is a graduate student in the Fruman lab.

Research Interests

B cell germinal center formation and antibody class switch recombination are important processes for an effective host immune defense. Dysregulation can lead to antibody driven autoimmune diseases such as systemic lupus erythematosus (SLE). mTOR signaling regulates the immune response and is highly activated in both human patient lymphocytes and B cells from lupus animal mouse models. However, little is known about the role of mTOR and its substrates in B cell differentiation and production of antibodies driving disease pathogenesis. Our preliminary data show that partial mTORC1 inhibition decreases class switching in vitro while minimally affecting proliferation of B cells. Mechanistic studies focusing on mTORC1 substrates show that 4E-BPs are inhibitory to antibody class switching. Since 4E-BPs interfere with eIF4E function in the mRNA cap-binding complex, these studies suggest that mTORC1 regulated cap-dependent translation may be a novel mechanism of controlling the antibody response. Thus, the goal of the project is to determine if activity of the cap-binding initiation factor eIF4E is important for antibody class switching. This study will not only illustrate how mTOR signaling is involved in B cell differentiation but may also potentially lead to new therapies for antibody driven autoimmune diseases such as SLE.


Office

3407 McGaugh Hall
(949) 824-2274

Lab

3407 McGaugh Hall
(949) 824-2274