Dr. Baram's Research Focus is:
Working to understand: (1) Mechanisms by which early life experience, including chromic stress infulences adult learning and memory. (2) Mechanisms by which early-life enriched sensory input enhances cognitive and emotional outcomes. (3) Mechanisms by which the normal brain becomes epileptic.
Scientific Focus: Stress, epilepsy, development, "programming", gene expression, epigenetics, plasticity, learning/memory, depression, imaging, molecular biology.
Methods: (1) Transgenic and viral-mediated control of gene expression in time and space. (2) In vitro organotypic slice cultures(hippocampus, hypothalamus). (3) Live multiphoton imaging of spine and synapse dynamics. (4) In vivo, high-field rodent MR imaging, including DTI, fMRI. (5) Epigenetics: chromatin immunoprecipitation (ChIP), ChIP seq, RNA seq, gene network analyses, informatics. (6) Molecular: rtPCR, ISH, Co-IP, pulldowns, pharmacological pathway dissection. (7) Cognitive and emotional behavioral tasks.
C237 Medical Sciences I